pDRIVE-CEA
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pDRIVE-hCEA pDRIVE bearing human CEA promoter - LacZ |
Show product |
20 µg |
pdrive-hcea
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pDRIVE5SEAP-hCEA pDRIVE bearing human CEA promoter - SEAP |
Show product |
20 µg |
pdrive5s-hcea
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pDRIVE5Lucia-hCEA pDRIVE bearing human CEA promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hcea
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Carcinoembryonic antigen (CEA) in pDRIVE expression plasmid
The carcinoembryonic antigen (CEA) is a cell surface glycoprotein that is overexpressed in colorectal and other cancers of epithelial cell origin. The CEA promoter has been used to induce tumor-selective expression of exogenous genes in human colorectal [1], gastric [2] and lung cancers.
In CEA producing cells, the CEA promoter has been shown to be as efficient as the SV40 enhancer/promoter in driving expression of therapeutic genes [1].
References:
1. Cao G. et al. 1998. Comparison of carcinoembryonic antigen promoter regions isolated from human colorectal carcinoma and normal adjacent mucosa to induce strong tumorspecific gene expression. Int J Cancer 78:242-247.
2. Lan KH. et al. 1997. In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma. Cancer Res. 57(19):4279-84.
Specifications
pDRIVE bearing human CEA promoter - LacZ, SEAP or Lucia
Gene Promoter: Carcinoembryonic Antigen
Specificity: Epithelial cancers
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin
pDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
