Toll-Like Receptors
InvivoGen provides an extensive list of tools to study Toll-like receptors
Toll-like receptors (TLRs) were the first pattern recognition receptors (PRRs) identified in mammals and to date are the best characterized. They initiate key inflammatory responses and also shape adaptative immunity.
All TLRs (10 in humans and 11 in mice) are type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail. They recognize diverse pathogen-associated molecular patterns (PAMPs) from bacteria, fungi, parasites, and viruses, including lipid-based bacterial cell wall components such as lipopolysaccharide (LPS) and lipopeptides, microbial protein components such as flagellin, and nucleic acids such as single-stranded or double-stranded RNA and CpG DNA.
They also react to certain damage-associated molecular patterns (DAMPs) from endogenous cells and the environment.
Choose from our growing collection
- TLR reporter cells
- A comprehensive choice of TLR ligands (agonists and antagonists)
- TLR antibodies for detection or neutralization
- TLR inhibitors such as signal transduction inhibitors and shRNAs
- fully-sequenced TLR and related genes
Key features of InvivoGen's products
- Cell lines from various tissue origins (THP-1, HEK 293, RAW cells)
- Each lot is functionally tested
- Guaranteed free of unwanted bacterial contaminants
