Cytosolic DNA Sensing

InvivoGen provides an extensive list of tools to study cytosolic DNA sensing

Double-stranded DNA (dsDNA) is a potent inducer of type I interferons (IFNs). Several sensors of cytosolic dsDNA have been identified, including cGAS, IFI-16, DDX41, and LRRFIP1, which trigger different signaling pathways in a cell-type-specific manner. AIM2 is another cytosolic DNA sensor, which upon activation forms an inflammasome leading to the secretion of IL-1β. The induction of type I IFNs by cytosolic DNA is mediated by the endoplasmic reticulum membrane protein STING (stimulator of IFN genes).

InvivoGen provides a growing library of tools to study cytosolic DNA sensors (CDSs) and STING signaling.

Choose from our comprehensive collection

CDS reporter cells
synthetic analogs of dsDNA as CDS ligands
CDS inhibitors
Fully sequenced CDS genes

Key features of InvivoGen's products

Each lot is functionally tested
Guaranteed free of unwanted bacterial contaminants

Read our review on cytosolic DNA sensors

➔ Everything around STING and our comprehensive library of STING-related products, you can find here.