Cyclic dinucleotide (CDN) sensor - STING
InvivoGen provides an extensive list of tools to study the STING pathway
STING (Stimulator of interferon genes), alternatively known as MPYS, TMEM173, MITA, and ERIS, is the key sensor of cytosolic nucleic acids. Initially thought to serve solely as an adaptor protein for mediating signaling by cytosolic DNA sensors (CDS), STING was found to be a direct sensor of cyclic dinucleotides (CDNs). CDNs are important messengers in bacteria, affecting numerous responses of prokaryotic cells, but also in mammalian cells acting as agonists of the innate immune response.
Interestingly, a variety of natural variants of human STING have been identified. The presence of nonsynonymous variants of STING, some in high frequencies, is indicative of its implicit role in disease, and therefore, considered as promising therapeutic targets.
Choose from our comprehensive collection
- Synthetic and natural cyclic dinucleotides
- STING inhibitor
- STING reporter cells
- STING variants, cloned and fully sequenced expression plasmids
Key features of InvivoGen's STING products
- Cell lines from various tissue origins (THP-1, HEK 293, RAW cells)
- Wildtype STING and important STING variants available
- Each lot is functionally tested
- Guaranteed free of unwanted bacterial contaminants
