Innate Immunity Signaling Inhibitors

InvivoGen offers a selection of inhibitors targeting different innate immunity pathways:

at the receptor/sensor level
at distinct steps of intracellular signaling

Depending on your needs, you may choose from our collection of high-quality and functionally-tested molecules:

PRR inhibitors

This family includes TLR, RLR, CDS & STING, CLR, and AhR inhibitors.

Inflammasome inhibitors

This family includes NLRP3 or AIM2 sensors and caspase inhibitors.

Kinase inhibitors

This family includes regulators of apical kinases, such as JAK1/JAK2, as well as inhibitors of downstream kinases, such as TBK1/IKKε, PI3K, IκB-α, MAPK, and MEK1/MEK2.

Autophagy modulators

This family includes small molecules targeting mTORc1 or other regulators of essential actors for the autophagy process.

See our Poster on Inhibitor Signaling Pathways

TLR Inhibitors		TLR Signaling Inhibitors, Antagonists, and Neutralizing Antibodies
RLR Pathway Inhibitors		RLR Signaling Inhibitors
Cytosolic DNA Sensing Inhibitors		Inhibitors of cGAS, AIM2, Kinase Signaling, and Protein Trafficking
CLR Inhibitor		Syk Inhibitor
AhR Inhibitor		AhR Antagonist
Inflammasome Inhibitors		NLRP3, AIM2, and Caspase Inhibitors
Kinase Inhibitors		Regulators of apical kinases (JAK1/JAK2) and downstream kinases (TBK1/IKKε, PI3K, IκB-α, MAPK, and MEK1/MEK2)
Regulated Cell Death Modulators
Autophagy Modulators		Inhibitors of mTOR Activation & Regulators of Autophagosome/Autophagolysosome Formation